3H0930 Topology Pattern and Classification of Transmembrane Proteins
نویسندگان
چکیده
منابع مشابه
Classification of Eukaryotic 7-tms Transmembrane Proteins by Binary Topology Pattern
G protein-coupled receptors (GPCRs) play extremely important functions in our body which are mainly to transduce chemical signals across cell membranes, therefore GPCRs are one of the target proteins in the biomedical field. GPCRs are found in large numbers in most eukaryotic genomes, although the only completely known three-dimensional structure in these families is that of rhodopsin from bovi...
متن کاملTransmembrane Topology Pattern and Detection of Transmembrane Protein Functions
Transmembrane (TM) proteins (TMPs) have important roles in the biological organisms [1, 2]. With the rapid increasing of the number of TMPs, a lot of efforts are made in attempt to classify TMP functions by sequence analysis, and in fact, some databases aimed for it have been constructed (e.g., Pfam [3]). Which characteristics of TMP could provide us important clues to its function? We suppose ...
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Functions of transmembrane (TM) proteins holding 20-30% [1] in individual proteomes are difficult to be inferred comprehensively based on only sequence similarity, which is partly because TM protein sequences of known function are lacking. Recent studies, however, revealed that TM protein functions are closely correlated to their TM topologies, i.e., the number of TM segments (TMSs), positions ...
متن کاملTOPDB: topology data bank of transmembrane proteins
The Topology Data Bank of Transmembrane Proteins (TOPDB) is the most complete and comprehensive collection of transmembrane protein datasets containing experimentally derived topology information currently available. It contains information gathered from the literature and from public databases available on the internet for more than a thousand transmembrane proteins. TOPDB collects details of ...
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Membrane proteins fulfil a number of tasks in cells, including signalling, cell-cell interaction, and the transportation of molecules. The prominence of these tasks makes membrane proteins an important target for clinical drugs. Because of the decreasing price of sequencing, the number of sequences known is increasing at such a rate that manual annotations cannot compete. Here, topology predict...
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ژورنال
عنوان ژورنال: Seibutsu Butsuri
سال: 2000
ISSN: 0582-4052,1347-4219
DOI: 10.2142/biophys.40.s192_4